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Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults

  • Michael Abouyannis*
  • , Yvonne K. Nyambura
  • , Samson Ngome
  • , Debra Riako
  • , Jennifer Musyoki
  • , Charles Muiruri
  • , Benedict Orindi
  • , Laura Else
  • , Alieu Amara
  • , Laura Dickinson
  • , Rachel H. Clare
  • , Laura Oana Albulescu
  • , Adam P. Westhorpe
  • , Jeroen Kool
  • , Ifedayo Adetifa
  • , Francis M. Ndungu
  • , Richard FitzGerald
  • , Saye Khoo
  • , David G. Lalloo
  • , Nicholas R. Casewell
  • Mainga Hamaluba
*Corresponding author for this work
  • Liverpool School of Tropical Medicine
  • KEMRI-Wellcome Research Programme
  • University of Liverpool
  • Centre for Snakebite Research & Interventions
  • Vrije Universiteit Amsterdam
  • Centre for Analytical Sciences Amsterdam
  • London School of Hygiene and Tropical Medicine
  • Liverpool University Hospitals NHS Foundation Trust
  • University of Oxford

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