Delivering effective, comprehensive, multiexercise component cardiac rehabilitation (CR) for chronic heart failure patients in low resource settings in sub-Saharan Africa: Queen Elizabeth Central Hospital—(QECH-CR) randomised CR study, Malawi

Alice Namanja*, Daston Nyondo, Tendai Banda, Ephraim Mndinda, ADRIAN MIDGLEY, James Hobkirk, Sean Carroll, Johnstone Kumwenda

*Corresponding author for this work

Research output: Contribution to journalArticle (journal)peer-review

Abstract

Background
The delivery of Cardiac Rehabilitation (CR) and attaining evidence-based treatment goals are challenging in developing countries, such as Malawi. The aims of this study were to (i) assess the effects of exercise training/ CR programme on cardiorespiratory and functional capacity of patients with chronic heart failure (CHF), and (ii) examine the effectiveness of a novel, hybrid CR delivery using integrated supervised hospital- and home-based caregiver approaches.
Methods
A pre-registered (UMIN000045380), randomised controlled trial of CR exercise therapy in patients with CHF was conducted between September 2021 and May 2022. Sixty CHF participants were randomly assigned into a parallel design-exercise therapy (ET) (n = 30) or standard of care (n = 30) groups. Resting hemodynamics, oxygen saturation, distance walked in six-minutes (6MWD) and estimated peak oxygen consumption (VO2 peak) constituted the outcome measures. The exercise group received supervised, group, circuit-based ET once weekly within the hospital setting and prescribed home-based exercise twice weekly for 12 weeks. Participants in both arms received a group-based, health behaviour change targeted education (usual care) at baseline, 8-, 12- and 16-weeks.
Results
Most of the participants were female (57%) with a mean age of 51.9 ±15.7 years. Sixty-five percent (65%) were in New York Heart Association class III, mostly with preserved left ventricular ejection fraction (HFpEF) (mean Left Ventricular Ejection Fraction 52.9 ±10.6%). The 12-weeks ET led to significant reductions in resting haemodynamic measures (all P <0.05). The ET showed significantly higher improvements in the 6MWD (103.6 versus 13.9 m, p<0.001) and VO2 peak (3.0 versus 0.4 ml·kg-1·min-1, p <0.001). Significant improvements in 6MWD and VO2 peak (both p<0.001), in favour of ET, were also observed across all follow-up timepoints.
Conclusion
This novel, randomised, hybrid ET-based CR, delivered to mainly HFpEF patients using an integrated hospital- and home-based approach effectively improved exercise tolerance, cardiorespiratory fitness capacities and reduced perceived exertion in a resource-limited setting.
Original languageEnglish
Pages (from-to)1-22
Number of pages22
JournalPLoS ONE
Volume19
Issue number5
Early online date24 May 2024
DOIs
Publication statusPublished - 24 May 2024

Keywords

  • Cardiac Rehabilitation (CR)
  • Chronic heart failure
  • Multi-exercise component
  • Low Resource Settings
  • sub-Saharan Africa
  • Malawi
  • Queen Elizabeth Central Hospital (QECH-CR)
  • randomised controlled trial
  • Healthcare interventions
  • Exercise programmes
  • Resource-Limited Environments
  • Heart Disease Management
  • Health Outcomes
  • Clinical trials
  • Chronic Disease Care

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