Correlations of visfatin with the lipidic medabolism in diabetic and obese patients

Ramona Gligor*, Dana Zdremtan, Luminita Pilat, Ioan Valentin Matei, Constantin Ionescu-Tirgoviste, Ioan Crisnic

*Corresponding author for this work

Research output: Contribution to journalArticle (journal)peer-review


Obesity and type 2 diabetes mellitus are the most frequent nutritional disorders found in the
developed countries and are associated with a high cardiovascular mortality and morbidity. They are
multifactorial associations and nutritional disorders, resulting from a genetic component and a
multitude of environmental factors. The clinical observation determined the association of the obesity
and diabetes mellitus with high blood pressure, dislipidemia and atherosclerosis. These conditions
represent a public health problem, due to the high prevalence and its association with high risk
cardiovascular diseases; both conditions have a high incidence in developed countries. Visfatin is an
adipocytokine identified in 2005, its name suggesting the idea that it is predominantly produced in the
visceral fat. It has a molecular weight of 52 kDa and it has in its structure, 491 aminoacid residues. It
is identical to the PBEF, that was described in 1994 as a lymphocytes produced cytokine.
Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalProceedings of the Romanian Academy Series B: Chemistry, Life Sciences and Geoscience
Issue number1
Publication statusPublished - 12 Dec 2011
Externally publishedYes


  • visfatin
  • diabetes mellitus
  • cholesterol
  • obesity
  • LDL
  • HDL


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