Contributions of evolutionary biology to the understanding of cancer

Constantin Ionescu-Tirgoviste; Ioan Valentin Matei; Bogdan Ivanus; Ana Maria Falcan

Contributions of evolutionary biology to the understanding of cancer

Constantin Ionescu-Tirgoviste^*
, Ioan Valentin Matei
, Bogdan Ivanus
, Ana Maria Falcan

^*Corresponding author for this work

Sf. Ioan Clinical Emergency Hospital, Bucharest, Romania
N.C. Paulescu National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania
Carol Davila University of Medicine and Pharmacy Bucharest, Romania

Research output: Contribution to journal › Review article › peer-review

Abstract

Evolutionary biology has proven itself to be a useful tool for medical oncologists and cancer
researchers. There is a growing body of evidence that suggests the emergence of cancer is itself a
Darwinian process, which abides by the rules of natural selection. Non-Darwinian evolutionary
processes such as genetic drift also play an important part. The consequences of these findings are
pivotal to the understanding of the failure that attempts at treatment have encountered thus far, as well
as to the design of future therapeutic approaches.

Original language	English
Pages (from-to)	183-190
Number of pages	8
Journal	Proceedings of the Romanian Academy Series B: Chemistry, Life Sciences and Geoscience
Volume	14
Issue number	3
Publication status	Published - 12 Jul 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
carcinogenesis
evolutionary theory
clonal evolution
acquired drug resistance

Access to Document

https://acad.ro/sectii2002/proceedingsChemistry/doc2012-3/art01Tirgoviste.pdf

Cite this

@article{c41d3293be334f248de7aa00a156af82,

title = "Contributions of evolutionary biology to the understanding of cancer",

abstract = "Evolutionary biology has proven itself to be a useful tool for medical oncologists and cancer researchers. There is a growing body of evidence that suggests the emergence of cancer is itself a Darwinian process, which abides by the rules of natural selection. Non-Darwinian evolutionary processes such as genetic drift also play an important part. The consequences of these findings are pivotal to the understanding of the failure that attempts at treatment have encountered thus far, as well as to the design of future therapeutic approaches.",

keywords = "cancer, carcinogenesis, evolutionary theory, clonal evolution, acquired drug resistance",

author = "Constantin Ionescu-Tirgoviste and Matei, \{Ioan Valentin\} and Bogdan Ivanus and Falcan, \{Ana Maria\}",

year = "2012",

month = jul,

day = "12",

language = "English",

volume = "14",

pages = "183--190",

journal = "Proceedings of the Romanian Academy Series B: Chemistry, Life Sciences and Geoscience",

issn = "1454-8267",

publisher = "Publishing House of the Romanian Academy",

number = "3",

}

TY - JOUR

T1 - Contributions of evolutionary biology to the understanding of cancer

AU - Ionescu-Tirgoviste, Constantin

AU - Matei, Ioan Valentin

AU - Ivanus, Bogdan

AU - Falcan, Ana Maria

PY - 2012/7/12

Y1 - 2012/7/12

N2 - Evolutionary biology has proven itself to be a useful tool for medical oncologists and cancer researchers. There is a growing body of evidence that suggests the emergence of cancer is itself a Darwinian process, which abides by the rules of natural selection. Non-Darwinian evolutionary processes such as genetic drift also play an important part. The consequences of these findings are pivotal to the understanding of the failure that attempts at treatment have encountered thus far, as well as to the design of future therapeutic approaches.

AB - Evolutionary biology has proven itself to be a useful tool for medical oncologists and cancer researchers. There is a growing body of evidence that suggests the emergence of cancer is itself a Darwinian process, which abides by the rules of natural selection. Non-Darwinian evolutionary processes such as genetic drift also play an important part. The consequences of these findings are pivotal to the understanding of the failure that attempts at treatment have encountered thus far, as well as to the design of future therapeutic approaches.

KW - cancer

KW - carcinogenesis

KW - evolutionary theory

KW - clonal evolution

KW - acquired drug resistance

M3 - Review article

SN - 1454-8267

VL - 14

SP - 183

EP - 190

JO - Proceedings of the Romanian Academy Series B: Chemistry, Life Sciences and Geoscience

JF - Proceedings of the Romanian Academy Series B: Chemistry, Life Sciences and Geoscience

IS - 3

ER -

Contributions of evolutionary biology to the understanding of cancer

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this