Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria.

Juliette Hughes*, Ke Liu, Antonius Plagge, Peter Wilson, Hazel Sutherland, Brendan Norman, Andrew Hughes, Craig Keenan, Anna Milan, Takao Sakai, Lakshminarayan Ranganath , James A Gallagher, George Bou-Gharios

*Corresponding author for this work

Research output: Contribution to journal › Article (journal) › peer-review

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Pharmacology, Toxicology and Pharmaceutical Science

Biochemistry, Genetics and Molecular Biology

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