@inbook{73b8635da22a4724a014cc2624b881da,
title = "Computational Systems Biology for Aging Research",
abstract = "Computational modelling is a key component of systems biology and integrates with the other tech- niques discussed thus far in this book by utilizing a myriad of data that are being generated to quan- titatively represent and simulate biological systems. This chapter will describe what computational modelling involves; the rationale for using it, and the appropriateness of modelling for investigating the aging process. How a model is assembled and the different theoretical frameworks that can be used to build a model are also discussed. In addition, the chapter will describe several models which demonstrate the effectiveness of each computational approach for investigating the constituents of a healthy aging trajectory. Specifically, a number of models will be showcased which focus on the complex age-related disorders associated with unhealthy aging. To conclude, we discuss the future applications of computational systems modelling to aging research.",
author = "{Mc Auley}, {Mark T} and Mooney, {Kathleen M}",
year = "2014",
month = oct,
day = "9",
doi = "DOI: 10.1159/000364928)",
language = "English",
isbn = "978-3-318-02729-7",
volume = "40",
series = "Interdisciplinary Topics in Gerontology and Geriatrics",
publisher = "Karger",
pages = "35--48",
editor = "{Yashin Jazwinski}, {Anatoli I} and Jazwinsk, {S Michal}",
booktitle = "Aging and Health – A Systems Biology Perspective.",
}