Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation

AE Morgan, KM Mooney, SJ Wilkinson, NA Pickles, MT Mc Auley

Research output: Contribution to journalArticle

34 Citations (Scopus)
18 Downloads (Pure)

Abstract

Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between cholesterol ingestion, synthesis, absorption, and excretion. The aim of this review is to discuss how ageing interacts with these processes. Firstly, we will present an overview of cholesterol metabolism. Following this, we discuss how the biological mechanisms which underpin cholesterol metabolism are effected by ageing. Included in this discussion are lipoprotein dynamics, cholesterol absorption/synthesis and the enterohepatic circulation/synthesis of bile acids. Moreover, we discuss the role of oxidative stress in the pathological progression of atherosclerosis and also discuss how cholesterol biosynthesis is effected by both the mammalian target of rapamycin and sirtuin pathways. Next, we examine how diet and alterations to the gut microbiome can be used to mitigate the impact ageing has on cholesterol metabolism. We conclude by discussing how mathematical models of cholesterol metabolism can be used to identify therapeutic interventions.
Original languageEnglish
Pages (from-to)108-124
JournalAgeing Research Reviews
Volume27
Early online date1 Apr 2016
DOIs
Publication statusE-pub ahead of print - 1 Apr 2016

Fingerprint

Metabolism
Aging of materials
Cholesterol
Bile Acids and Salts
Ingestion (engines)
Steroid hormones
Cell Membrane Structures
Enterohepatic Circulation
Oxidative stress
Biosynthesis
Sirolimus
Cell membranes
Nutrition
Human Body
Atherosclerosis
Oxidative Stress
Theoretical Models
Eating
Steroids
Hormones

Cite this

Morgan, AE ; Mooney, KM ; Wilkinson, SJ ; Pickles, NA ; Mc Auley, MT. / Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation. In: Ageing Research Reviews. 2016 ; Vol. 27. pp. 108-124.
@article{82973dd7d64d48bab6562eaf589a18f0,
title = "Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation",
abstract = "Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between cholesterol ingestion, synthesis, absorption, and excretion. The aim of this review is to discuss how ageing interacts with these processes. Firstly, we will present an overview of cholesterol metabolism. Following this, we discuss how the biological mechanisms which underpin cholesterol metabolism are effected by ageing. Included in this discussion are lipoprotein dynamics, cholesterol absorption/synthesis and the enterohepatic circulation/synthesis of bile acids. Moreover, we discuss the role of oxidative stress in the pathological progression of atherosclerosis and also discuss how cholesterol biosynthesis is effected by both the mammalian target of rapamycin and sirtuin pathways. Next, we examine how diet and alterations to the gut microbiome can be used to mitigate the impact ageing has on cholesterol metabolism. We conclude by discussing how mathematical models of cholesterol metabolism can be used to identify therapeutic interventions.",
author = "AE Morgan and KM Mooney and SJ Wilkinson and NA Pickles and {Mc Auley}, MT",
year = "2016",
month = "4",
day = "1",
doi = "http://dx.doi.org/10.1016/j.arr.2016.03.008",
language = "English",
volume = "27",
pages = "108--124",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier",

}

Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation. / Morgan, AE; Mooney, KM; Wilkinson, SJ; Pickles, NA; Mc Auley, MT.

In: Ageing Research Reviews, Vol. 27, 01.04.2016, p. 108-124.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cholesterol Metabolism: A Review of How Ageing Disrupts the Biological Mechanisms Responsible for its Regulation

AU - Morgan, AE

AU - Mooney, KM

AU - Wilkinson, SJ

AU - Pickles, NA

AU - Mc Auley, MT

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between cholesterol ingestion, synthesis, absorption, and excretion. The aim of this review is to discuss how ageing interacts with these processes. Firstly, we will present an overview of cholesterol metabolism. Following this, we discuss how the biological mechanisms which underpin cholesterol metabolism are effected by ageing. Included in this discussion are lipoprotein dynamics, cholesterol absorption/synthesis and the enterohepatic circulation/synthesis of bile acids. Moreover, we discuss the role of oxidative stress in the pathological progression of atherosclerosis and also discuss how cholesterol biosynthesis is effected by both the mammalian target of rapamycin and sirtuin pathways. Next, we examine how diet and alterations to the gut microbiome can be used to mitigate the impact ageing has on cholesterol metabolism. We conclude by discussing how mathematical models of cholesterol metabolism can be used to identify therapeutic interventions.

AB - Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile acids, in addition to providing structure to cell membranes. Whole body cholesterol metabolism is maintained by a highly coordinated balancing act between cholesterol ingestion, synthesis, absorption, and excretion. The aim of this review is to discuss how ageing interacts with these processes. Firstly, we will present an overview of cholesterol metabolism. Following this, we discuss how the biological mechanisms which underpin cholesterol metabolism are effected by ageing. Included in this discussion are lipoprotein dynamics, cholesterol absorption/synthesis and the enterohepatic circulation/synthesis of bile acids. Moreover, we discuss the role of oxidative stress in the pathological progression of atherosclerosis and also discuss how cholesterol biosynthesis is effected by both the mammalian target of rapamycin and sirtuin pathways. Next, we examine how diet and alterations to the gut microbiome can be used to mitigate the impact ageing has on cholesterol metabolism. We conclude by discussing how mathematical models of cholesterol metabolism can be used to identify therapeutic interventions.

U2 - http://dx.doi.org/10.1016/j.arr.2016.03.008

DO - http://dx.doi.org/10.1016/j.arr.2016.03.008

M3 - Article

VL - 27

SP - 108

EP - 124

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

ER -