Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats

Dorothy Tse; Lucia Privitera; Anna C. Norton; Francesco Gobbo; Patrick Spooner; Tomonori Takeuchi; Stephen J. Martin; Richard G. M. Morris

doi:10.1073/pnas.2307275120

Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats

Dorothy Tse, Lucia Privitera, Anna C. Norton, Francesco Gobbo, Patrick Spooner, Tomonori Takeuchi, Stephen J. Martin^*, Richard G. M. Morris^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article (journal) › peer-review

14 Citations (Scopus)

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Abstract

Memory formation is typically divided into phases associated with encoding, storage, consolidation, and retrieval. The neural determinants of these phases are thought to differ. This study first investigated the impact of the experience of novelty in rats incurred at a different time, before or after, the precise moment of memory encoding. Memory retention was enhanced. Optogenetic activation of the locus coeruleus mimicked this enhancement induced by novelty, both when given before and after the moment of encoding. Optogenetic activation of the locus coeruleus also induced a slow-onset potentiation of field potentials in area CA1 of the hippocampus evoked by CA3 stimulation. Despite the locus coeruleus being considered a primarily noradrenergic area, both effects of such stimulation were blocked by the dopamine D1/D5 receptor antagonist SCH 23390. These findings substantiate and enrich the evidence implicating the locus coeruleus in cellular aspects of memory consolidation in hippocampus.

Original language	English
Article number	e2307275120
Pages (from-to)	1-12
Number of pages	12
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	120
Issue number	46
Early online date	6 Nov 2023
DOIs	https://doi.org/10.1073/pnas.2307275120
Publication status	Published - 14 Nov 2023

Keywords

memory
synaptic tagging and capture
long term potentiation
locus coeruleus
dopamine
Hippocampus/physiology
Neurons/physiology
Locus Coeruleus/physiology
Rats
Optogenetics
Animals
Norepinephrine/pharmacology
Long-Term Potentiation/physiology

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Tse, D., Privitera, L., Norton, A. C., Gobbo, F., Spooner, P., Takeuchi, T., Martin, S. J., & Morris, R. G. M. (2023). Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats. Proceedings of the National Academy of Sciences of the United States of America, 120(46), 1-12. Article e2307275120. https://doi.org/10.1073/pnas.2307275120

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abstract = "Memory formation is typically divided into phases associated with encoding, storage, consolidation, and retrieval. The neural determinants of these phases are thought to differ. This study first investigated the impact of the experience of novelty in rats incurred at a different time, before or after, the precise moment of memory encoding. Memory retention was enhanced. Optogenetic activation of the locus coeruleus mimicked this enhancement induced by novelty, both when given before and after the moment of encoding. Optogenetic activation of the locus coeruleus also induced a slow-onset potentiation of field potentials in area CA1 of the hippocampus evoked by CA3 stimulation. Despite the locus coeruleus being considered a primarily noradrenergic area, both effects of such stimulation were blocked by the dopamine D1/D5 receptor antagonist SCH 23390. These findings substantiate and enrich the evidence implicating the locus coeruleus in cellular aspects of memory consolidation in hippocampus.",

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author = "Dorothy Tse and Lucia Privitera and Norton, {Anna C.} and Francesco Gobbo and Patrick Spooner and Tomonori Takeuchi and Martin, {Stephen J.} and Morris, {Richard G. M.}",

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Tse, D, Privitera, L, Norton, AC, Gobbo, F, Spooner, P, Takeuchi, T, Martin, SJ & Morris, RGM 2023, 'Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 46, e2307275120, pp. 1-12. https://doi.org/10.1073/pnas.2307275120

Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats. / Tse, Dorothy; Privitera, Lucia; Norton, Anna C. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, No. 46, e2307275120, 14.11.2023, p. 1-12.

Research output: Contribution to journal › Article (journal) › peer-review

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AU - Privitera, Lucia

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AU - Spooner, Patrick

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Tse D, Privitera L, Norton AC, Gobbo F, Spooner P, Takeuchi T et al. Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats. Proceedings of the National Academy of Sciences of the United States of America. 2023 Nov 14;120(46):1-12. e2307275120. Epub 2023 Nov 6. doi: 10.1073/pnas.2307275120

Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats

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