TY - JOUR
T1 - Ca2+ signalling in the control of motility and guidance in mammalian sperm
AU - Publicover, Stephen John
AU - Giojalas, Laura Cecilia
AU - Teves, Maria Eugenia
AU - de Oliveira, Gisela Sofia Mendes Machado
AU - Garcia, Aduen Andres Morales
AU - Barratt, Christopher Lowther Robert
AU - Harper, Claire Victoria
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+]i signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+]i in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+]i and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+]i and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm..
AB - Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+]i signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+]i in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+]i and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+]i and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm..
KW - Animals
KW - Calcium/physiology
KW - Homeostasis
KW - Humans
KW - Male
KW - Mammals
KW - Nucleotides, Cyclic/physiology
KW - Progesterone/physiology
KW - Signal Transduction
KW - Sperm Motility/physiology
KW - Spermatozoa/physiology
U2 - 10.2741/3105
DO - 10.2741/3105
M3 - Review article
C2 - 18508611
SN - 1093-9946
VL - 13
SP - 5623
EP - 5637
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
ER -