TY - JOUR
T1 - Building Global Collaborative Research Networks in Paediatric Critical Care
T2 - a roadmap
AU - Schlapbach, Luregn J.
AU - Ramnarayan, Padmanabhan
AU - Gibbons, Kristen S.
AU - Morrow, Brenda M.
AU - Napolitano, Natalie
AU - Tume, Lyvonne N.
AU - Argent, Andrew C.
AU - Deep, Akash
AU - Lee, Jan Hau
AU - Peters, Mark J.
AU - Agus, Michael S.D.
AU - Appiah, John Adabie
AU - Armstrong, Jennifer
AU - Bacha, Tigist
AU - Butt, Warwick
AU - de Souza, Daniela Carla
AU - Fernández-Sarmiento, Jaime
AU - Flori, Heidi R.
AU - Fontela, Patricia
AU - Gelbart, Ben
AU - González-Dambrauskas, Sebastián
AU - Ikeyama, Takanari
AU - Jabornisky, Roberto
AU - Jayashree, Muralidharan
AU - Kazzaz, Yasser M.
AU - Kneyber, Martin C.J.
AU - Long, Debbie
AU - Njirimmadzi, Jenala
AU - Samransamruajkit, Rujipat
AU - Asperen, Roelie M.Wösten van
AU - Wang, Quan
AU - O'Hearn, Katie
AU - Menon, Kusum
AU - Australian and New Zealand Intensive Care Society Paediatric Study Group
AU - Brazilian Research Network in Pediatric Intensive Care
AU - Canadian Critical Care Trials Group
AU - European Society of Paediatric and Neonatal Intensive Care
AU - Pediatric Collaborative Network of Latin America
AU - Pediatric Acute & Critical Care Medicine Asian Network
AU - Pediatric Acute Lung Injury and Sepsis Investigators
AU - United Kingdom Paediatric Critical Care Society Study Group
AU - Pediatric Intensive Care Latin-American Society
AU - World Federation of Pediatric Intensive & Critical Care Societies
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.
PY - 2025/2/26
Y1 - 2025/2/26
N2 - Paediatric critical care units are designed for children at a vulnerable stage of development, yet the evidence base for practice and policy in paediatric critical care remains scarce. In this Health Policy, we present a roadmap providing strategic guidance for international paediatric critical care trials. We convened a multidisciplinary group of 32 paediatric critical care experts from six continents representing paediatric critical care research networks and groups. The group identified key challenges to paediatric critical care research, including lower patient numbers than for adult critical care, heterogeneity related to cognitive development, comorbidities and illness or injury, consent challenges, disproportionately little research funding for paediatric critical care, and poor infrastructure in resource-limited settings. A seven-point roadmap was proposed: (1) formation of an international paediatric critical care research network; (2) development of a web-based toolkit library to support paediatric critical care trials; (3) establishment of a global paediatric critical care trial repository, including systematic prioritisation of topics and populations for interventional trials; (4) development of a harmonised trial minimum set of trial data elements and data dictionary; (5) building of infrastructure and capability to support platform trials; (6) funder advocacy; and (7) development of a collaborative implementation programme. Implementation of this roadmap will contribute to the successful design and conduct of trials that match the needs of globally diverse paediatric populations.
AB - Paediatric critical care units are designed for children at a vulnerable stage of development, yet the evidence base for practice and policy in paediatric critical care remains scarce. In this Health Policy, we present a roadmap providing strategic guidance for international paediatric critical care trials. We convened a multidisciplinary group of 32 paediatric critical care experts from six continents representing paediatric critical care research networks and groups. The group identified key challenges to paediatric critical care research, including lower patient numbers than for adult critical care, heterogeneity related to cognitive development, comorbidities and illness or injury, consent challenges, disproportionately little research funding for paediatric critical care, and poor infrastructure in resource-limited settings. A seven-point roadmap was proposed: (1) formation of an international paediatric critical care research network; (2) development of a web-based toolkit library to support paediatric critical care trials; (3) establishment of a global paediatric critical care trial repository, including systematic prioritisation of topics and populations for interventional trials; (4) development of a harmonised trial minimum set of trial data elements and data dictionary; (5) building of infrastructure and capability to support platform trials; (6) funder advocacy; and (7) development of a collaborative implementation programme. Implementation of this roadmap will contribute to the successful design and conduct of trials that match the needs of globally diverse paediatric populations.
KW - Child
KW - Clinical trials
KW - International
KW - Intensive care
KW - Network
KW - Critical Care/organization & administration
KW - Global Health
KW - Humans
KW - Biomedical Research/organization & administration
KW - International Cooperation
KW - Clinical Trials as Topic
KW - Intensive Care Units, Pediatric/organization & administration
KW - Pediatrics/organization & administration
U2 - 10.1016/S2352-4642(24)00303-1
DO - 10.1016/S2352-4642(24)00303-1
M3 - Article (journal)
C2 - 39718171
AN - SCOPUS:85214328400
SN - 2352-4642
SN - 2352-4650
VL - 9
SP - 138
EP - 150
JO - The Lancet Child and Adolescent Health
JF - The Lancet Child and Adolescent Health
IS - 2
ER -
SDG 10 Reduced Inequalities