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Alterations in long-range functional connectivity between distinct brain regions are thought to contribute to the encoding of memory. However, little is known about how the activation of an existing network of neocortical and hippocampal regions might support the assimilation of relevant new information into the preexisting knowledge structure or 'schema'. Using functional mapping for expression of plasticity-related immediate early gene products, we sought to identify the long-range functional network of paired-associate memory, and the encoding and assimilation of relevant new paired-associates. Correlational and clustering analyses for expression of immediate early gene products revealed that midline neocortical-hippocampal connectivity is strongly associated with successful memory encoding of new paired-associates against the backdrop of the schema, compared to both (1) unsuccessful memory encoding of new paired-associates that are not relevant to the schema, and (2) the mere retrieval of the previously learned schema. These findings suggest that the certain midline neocortical and hippocampal networks support the assimilation of newly encoded associative memories into a relevant schema. [Abstract copyright: © 2022. The Author(s).]
Original languageEnglish
Article number24
JournalMolecular Brain
Early online date24 Mar 2022
Publication statusE-pub ahead of print - 24 Mar 2022


  • Anterior cingulate cortex
  • Functional network
  • Prelimbic cortex
  • Paired-associate memory
  • Hippocampus
  • Memory assimilation
  • Anterior retrosplenial cortex
  • Schema


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