Blood–brain barrier disruption in dementia: Nano‐solutions as new treatment options: Nano-solutions as new treatment options

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Abstract

Candidate drugs targeting the central nervous system (CNS) demonstrate extremely low clinical success rates, with more than 98% of potential treatments being discontinued due to poor blood-brain barrier (BBB) permeability. Neurological conditions were shown to be the second leading cause of death globally in 2016, with the number of people currently affected by neurological disorders increasing rapidly. This increasing trend, along with an inability to develop BBB permeating drugs, is presenting a major hurdle in the treatment of CNS-related disorders, like dementia. To overcome this, it is necessary to understand the structure and function of the BBB, including the transport of molecules across its interface in both healthy and pathological conditions. The use of CNS drug carriers is rapidly gaining popularity in CNS research due to their ability to target BBB transport systems. Further research and development of drug delivery vehicles could provide essential information that can be used to develop novel treatments for neurological conditions. This review discusses the BBB and its transport systems and evaluates the potential of using nanoparticle-based delivery systems as drug carriers for CNS disease with a focus on dementia.

Original languageEnglish
Pages (from-to)1-27
Number of pages27
JournalThe European journal of neuroscience
Early online date28 Dec 2023
DOIs
Publication statusPublished - 28 Dec 2023

Keywords

  • Alzheimer’s disease
  • blood–brain barrier
  • dementia
  • drug delivery
  • nanogels
  • nanoparticles
  • General Neuroscience
  • Alzheimer's disease

Research Institutes

  • Health Research Institute

Research Centres

  • Cardio-Respiratory Research Centre
  • Data Science STEM Research Centre
  • Centre for Intelligent Visual Computing Research

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