Are Cross-Linked Actin Networks (CLANs) Associated With Age-related Changes Of The Trabecular Meshwork

N. Pollock; L. Currie; L. Paraoan; A.F. Clark; I. Grierson

Are Cross-Linked Actin Networks (CLANs) Associated With Age-related Changes Of The Trabecular Meshwork

N. Pollock
, L. Currie
, L. Paraoan
, A.F. Clark
, I. Grierson

Biology

Research output: Contribution to journal › Article (journal) › peer-review

Abstract

We have previously shown that Cross-linked Actin Networks (CLANs) can be induced by aqueous humor and TGF-β2 in vitro and have been identified in human trabecular meshwork (TM) tissue. Although CLANs occur more frequently in glaucomatous TM tissue ex vivo, they are also present in the TM of normal donors. In this study we wish to determine whether CLANs are an age-related feature of TM cells.

Original language	English
Pages (from-to)	e3243
Journal	Investigative Ophthalmology and Visual Science
Volume	53
Issue number	14
Publication status	Published - 1 Mar 2012

Cite this

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title = "Are Cross-Linked Actin Networks (CLANs) Associated With Age-related Changes Of The Trabecular Meshwork",

abstract = "We have previously shown that Cross-linked Actin Networks (CLANs) can be induced by aqueous humor and TGF-β2 in vitro and have been identified in human trabecular meshwork (TM) tissue. Although CLANs occur more frequently in glaucomatous TM tissue ex vivo, they are also present in the TM of normal donors. In this study we wish to determine whether CLANs are an age-related feature of TM cells.",

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AU - Paraoan, L.

AU - Clark, A.F.

AU - Grierson, I.

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N2 - We have previously shown that Cross-linked Actin Networks (CLANs) can be induced by aqueous humor and TGF-β2 in vitro and have been identified in human trabecular meshwork (TM) tissue. Although CLANs occur more frequently in glaucomatous TM tissue ex vivo, they are also present in the TM of normal donors. In this study we wish to determine whether CLANs are an age-related feature of TM cells.

AB - We have previously shown that Cross-linked Actin Networks (CLANs) can be induced by aqueous humor and TGF-β2 in vitro and have been identified in human trabecular meshwork (TM) tissue. Although CLANs occur more frequently in glaucomatous TM tissue ex vivo, they are also present in the TM of normal donors. In this study we wish to determine whether CLANs are an age-related feature of TM cells.

M3 - Article (journal)

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VL - 53

SP - e3243

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 14

ER -

Are Cross-Linked Actin Networks (CLANs) Associated With Age-related Changes Of The Trabecular Meshwork

Abstract

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