Anterior cingulate cortex in schema assimilation and expression

Szu-Han Wang, Dorothy Tse, Richard G M Morris

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.

Original languageEnglish
Pages (from-to)315-8
Number of pages4
JournalLearning and Memory
Volume19
Issue number8
DOIs
Publication statusPublished - 16 Jul 2012

Keywords

  • 2-Amino-5-phosphonovalerate/pharmacology
  • 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
  • Analysis of Variance
  • Animals
  • Association Learning/drug effects
  • Conditioning, Operant/drug effects
  • Cues
  • Early Growth Response Protein 1/metabolism
  • Excitatory Amino Acid Antagonists/pharmacology
  • Gyrus Cinguli/drug effects
  • Hippocampus/drug effects
  • Male
  • Mental Recall/drug effects
  • Neural Pathways/drug effects
  • Rats
  • Reaction Time/drug effects
  • Reward
  • Time Factors

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