Anterior cingulate cortex in schema assimilation and expression

Szu-Han Wang; Dorothy Tse; Richard G M Morris

doi:10.1101/lm.026336.112

Anterior cingulate cortex in schema assimilation and expression

Szu-Han Wang, Dorothy Tse, Richard G M Morris

Psychology

University of Edinburgh

Research output: Contribution to journal › Article (journal) › peer-review

64 Citations (Scopus)

Abstract

In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.

Original language	English
Pages (from-to)	315-8
Number of pages	4
Journal	Learning and Memory
Volume	19
Issue number	8
DOIs	https://doi.org/10.1101/lm.026336.112
Publication status	Published - 16 Jul 2012

Keywords

2-Amino-5-phosphonovalerate/pharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
Analysis of Variance
Animals
Association Learning/drug effects
Conditioning, Operant/drug effects
Cues
Early Growth Response Protein 1/metabolism
Excitatory Amino Acid Antagonists/pharmacology
Gyrus Cinguli/drug effects
Hippocampus/drug effects
Male
Mental Recall/drug effects
Neural Pathways/drug effects
Rats
Reaction Time/drug effects
Reward
Time Factors

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10.1101/lm.026336.112

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title = "Anterior cingulate cortex in schema assimilation and expression",

abstract = "In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.",

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author = "Szu-Han Wang and Dorothy Tse and Morris, {Richard G M}",

year = "2012",

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doi = "10.1101/lm.026336.112",

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T1 - Anterior cingulate cortex in schema assimilation and expression

AU - Wang, Szu-Han

AU - Tse, Dorothy

AU - Morris, Richard G M

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N2 - In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.

AB - In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.

KW - 2-Amino-5-phosphonovalerate/pharmacology

KW - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology

KW - Analysis of Variance

KW - Animals

KW - Association Learning/drug effects

KW - Conditioning, Operant/drug effects

KW - Cues

KW - Early Growth Response Protein 1/metabolism

KW - Excitatory Amino Acid Antagonists/pharmacology

KW - Gyrus Cinguli/drug effects

KW - Hippocampus/drug effects

KW - Male

KW - Mental Recall/drug effects

KW - Neural Pathways/drug effects

KW - Rats

KW - Reaction Time/drug effects

KW - Reward

KW - Time Factors

U2 - 10.1101/lm.026336.112

DO - 10.1101/lm.026336.112

M3 - Article (journal)

C2 - 22802592

SN - 1072-0502

VL - 19

SP - 315

EP - 318

JO - Learning and Memory

JF - Learning and Memory

IS - 8

ER -

Anterior cingulate cortex in schema assimilation and expression

Abstract

Keywords

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