Airway ion transport on the first postnatal day in infants delivered vaginally or by elective caesarian section

E. Gaillard, N. Shaw, H. Wallace, N. Subhedar, K. Southern

Research output: Contribution to conferencePaper

Abstract

To determine airway ion transport in term infants on the first day of postnatal life, and to test the hypothesis that infants born without labor have reduced sodium absorption, we measured nasal potential difference using a modified perfusion protocol suitable for newborn infants. We examined maximal stable baseline potential difference, the change after perfusion with 10(-4) M amiloride (Deltaamil), and the change after perfusion with a zero-chloride solution (Deltazero Cl-) in infants born after elective cesarean section (n = 21) or normal labor (n = 20). Maximal stable baseline potential difference was not different in the two cohorts (-24.0 mV, range -9 to -64 mV versus -25.5 mV, range -6 to -44 mV). The majority of infants in both cohorts showed a substantial fall in potential difference after amiloride perfusion, and there was little capacity for chloride secretion. These results demonstrate a fluid absorptive pattern in the airways on the first postnatal day. In these well infants, the ion transport phenotype was not dependent on the presence or absence of labor.
Original languageEnglish
Publication statusPublished - 2002
EventPhysiotherapy Research Society Annual Conference - Liverpool, United Kingdom
Duration: 25 Dec 2002 → …

Conference

ConferencePhysiotherapy Research Society Annual Conference
CountryUnited Kingdom
CityLiverpool
Period25/12/02 → …

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Ion Transport
Cesarean Section
Perfusion
Amiloride
Chlorides
Sodium
Newborn Infant
Phenotype

Cite this

Gaillard, E., Shaw, N., Wallace, H., Subhedar, N., & Southern, K. (2002). Airway ion transport on the first postnatal day in infants delivered vaginally or by elective caesarian section. Paper presented at Physiotherapy Research Society Annual Conference, Liverpool, United Kingdom.
Gaillard, E. ; Shaw, N. ; Wallace, H. ; Subhedar, N. ; Southern, K. / Airway ion transport on the first postnatal day in infants delivered vaginally or by elective caesarian section. Paper presented at Physiotherapy Research Society Annual Conference, Liverpool, United Kingdom.
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abstract = "To determine airway ion transport in term infants on the first day of postnatal life, and to test the hypothesis that infants born without labor have reduced sodium absorption, we measured nasal potential difference using a modified perfusion protocol suitable for newborn infants. We examined maximal stable baseline potential difference, the change after perfusion with 10(-4) M amiloride (Deltaamil), and the change after perfusion with a zero-chloride solution (Deltazero Cl-) in infants born after elective cesarean section (n = 21) or normal labor (n = 20). Maximal stable baseline potential difference was not different in the two cohorts (-24.0 mV, range -9 to -64 mV versus -25.5 mV, range -6 to -44 mV). The majority of infants in both cohorts showed a substantial fall in potential difference after amiloride perfusion, and there was little capacity for chloride secretion. These results demonstrate a fluid absorptive pattern in the airways on the first postnatal day. In these well infants, the ion transport phenotype was not dependent on the presence or absence of labor.",
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Gaillard, E, Shaw, N, Wallace, H, Subhedar, N & Southern, K 2002, 'Airway ion transport on the first postnatal day in infants delivered vaginally or by elective caesarian section' Paper presented at Physiotherapy Research Society Annual Conference, Liverpool, United Kingdom, 25/12/02, .

Airway ion transport on the first postnatal day in infants delivered vaginally or by elective caesarian section. / Gaillard, E.; Shaw, N.; Wallace, H.; Subhedar, N.; Southern, K.

2002. Paper presented at Physiotherapy Research Society Annual Conference, Liverpool, United Kingdom.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Airway ion transport on the first postnatal day in infants delivered vaginally or by elective caesarian section

AU - Gaillard, E.

AU - Shaw, N.

AU - Wallace, H.

AU - Subhedar, N.

AU - Southern, K.

PY - 2002

Y1 - 2002

N2 - To determine airway ion transport in term infants on the first day of postnatal life, and to test the hypothesis that infants born without labor have reduced sodium absorption, we measured nasal potential difference using a modified perfusion protocol suitable for newborn infants. We examined maximal stable baseline potential difference, the change after perfusion with 10(-4) M amiloride (Deltaamil), and the change after perfusion with a zero-chloride solution (Deltazero Cl-) in infants born after elective cesarean section (n = 21) or normal labor (n = 20). Maximal stable baseline potential difference was not different in the two cohorts (-24.0 mV, range -9 to -64 mV versus -25.5 mV, range -6 to -44 mV). The majority of infants in both cohorts showed a substantial fall in potential difference after amiloride perfusion, and there was little capacity for chloride secretion. These results demonstrate a fluid absorptive pattern in the airways on the first postnatal day. In these well infants, the ion transport phenotype was not dependent on the presence or absence of labor.

AB - To determine airway ion transport in term infants on the first day of postnatal life, and to test the hypothesis that infants born without labor have reduced sodium absorption, we measured nasal potential difference using a modified perfusion protocol suitable for newborn infants. We examined maximal stable baseline potential difference, the change after perfusion with 10(-4) M amiloride (Deltaamil), and the change after perfusion with a zero-chloride solution (Deltazero Cl-) in infants born after elective cesarean section (n = 21) or normal labor (n = 20). Maximal stable baseline potential difference was not different in the two cohorts (-24.0 mV, range -9 to -64 mV versus -25.5 mV, range -6 to -44 mV). The majority of infants in both cohorts showed a substantial fall in potential difference after amiloride perfusion, and there was little capacity for chloride secretion. These results demonstrate a fluid absorptive pattern in the airways on the first postnatal day. In these well infants, the ion transport phenotype was not dependent on the presence or absence of labor.

M3 - Paper

ER -

Gaillard E, Shaw N, Wallace H, Subhedar N, Southern K. Airway ion transport on the first postnatal day in infants delivered vaginally or by elective caesarian section. 2002. Paper presented at Physiotherapy Research Society Annual Conference, Liverpool, United Kingdom.