ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria

Morgan Anne Feeney, Jake Terry Newitt, Emily Addington, Lis Algora-Gallardo, Craig Allan, Lucas Balis, Anna S. Birke, Laia Castaño-Espriu, Louise K. Charkoudian, Rebecca Devine, Damien Gayrard, Jacob Hamilton, Oliver Hennrich, Paul A. Hoskisson, Molly Keith-Baker, Joshua G. Klein, Worarat Kruasuwan, David R. Mark, Yvonne Mast, Rebecca E. McHughThomas C. McLean, Elmira Mohit, John T. Munnoch, Jordan Murray, Katie Noble, Hiroshi Otani, Jonathan Parra, Camila F. Pereira, Louisa Perry, Linamaria Pintor-Escobar, Leighton Pritchard, Samuel M. M. Prudence, Alicia H. Russell, Jana K. Schniete, Ryan F. Seipke, Nelly Sélem-Mojica, Agustina Undabarrena, Kristiina Vind, Gilles P. van Wezel, Barrie Wilkinson, Sarah F. Worsley, Katherine R. Duncan, Lorena T. Fernández-Martínez, Matthew I. Hutchings

Research output: Contribution to journalArticle (journal)peer-review

Abstract

Actinobacteria is an ancient phylum of Gram-positive bacteria with a characteristic high GC content to their DNA. The ActinoBase Wiki is focused on the filamentous actinobacteria, such as Streptomyces species, and the techniques and growth conditions used to study them. These organisms are studied because of their complex developmental life cycles and diverse specialised metabolism which produces many of the antibiotics currently used in the clinic. ActinoBase is a community effort that provides valuable and freely accessible resources, including protocols and practical information about filamentous actinobacteria. It is aimed at enabling knowledge exchange between members of the international research community working with these fascinating bacteria. ActinoBase is an anchor platform that underpins worldwide efforts to understand the ecology, biology and metabolic potential of these organisms. There are two key differences that set ActinoBase apart from other Wiki-based platforms: [] ActinoBase is specifically aimed at researchers working on filamentous actinobacteria and is tailored to help users overcome challenges working with these bacteria and [] it provides a freely accessible resource with global networking opportunities for researchers with a broad range of experience in this field.
Original languageEnglish
Article number000824
JournalMicrobial genomics
Volume8
Issue number7
Early online date1 Jul 2022
DOIs
Publication statusPublished - 1 Jul 2022

Keywords

  • actinobacteria
  • antibiotics
  • BGCs
  • CRISPR
  • specialised metabolites
  • Streptomyces

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