Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas

S Miyakis; T Liloglou; S Kearney; G Xinarianos; D A Spandidos; J K Field

doi:10.1016/s0169-5002(02)00506-8

Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas

S Miyakis, T Liloglou, S Kearney, G Xinarianos, D A Spandidos, J K Field

Roy Castle International Centre for Lung Cancer Research

Research output: Contribution to journal › Article (journal) › peer-review

20 Citations (Scopus)

Abstract

In this study we have examined 79 primary non-small cell lung tumours for the presence of mutations of the VHL gene as well as for allelic imbalance at the gene surrounding loci. While allelic imbalance was found in 83% of specimens, frequently affecting the whole 3p25-p26 region, no mutations were detected in the VHL coding region. The fractional regional loss (FRL) was significantly higher in squamous cell carcinomas (0.746) than adenocarcinomas (0.493) (Wilcoxon P=0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC.

Original language	English
Pages (from-to)	273-7
Number of pages	5
Journal	Lung Cancer
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/s0169-5002(02)00506-8
Publication status	Published - 1 Mar 2003

Keywords

Adenocarcinoma/genetics
Aged
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Squamous Cell/genetics
Chromosomes, Human, Pair 3
DNA Mutational Analysis
Genes, Tumor Suppressor
Humans
Ligases/analysis
Loss of Heterozygosity
Lung Neoplasms/genetics
Middle Aged
Tumor Suppressor Proteins
Ubiquitin-Protein Ligases
Von Hippel-Lindau Tumor Suppressor Protein
von Hippel-Lindau Disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/s0169-5002(02)00506-8

Cite this

@article{391e362c696a42218f3a2e4e47eb897e,

title = "Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas",

abstract = "In this study we have examined 79 primary non-small cell lung tumours for the presence of mutations of the VHL gene as well as for allelic imbalance at the gene surrounding loci. While allelic imbalance was found in 83% of specimens, frequently affecting the whole 3p25-p26 region, no mutations were detected in the VHL coding region. The fractional regional loss (FRL) was significantly higher in squamous cell carcinomas (0.746) than adenocarcinomas (0.493) (Wilcoxon P=0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC.",

keywords = "Adenocarcinoma/genetics, Aged, Carcinoma, Non-Small-Cell Lung/genetics, Carcinoma, Squamous Cell/genetics, Chromosomes, Human, Pair 3, DNA Mutational Analysis, Genes, Tumor Suppressor, Humans, Ligases/analysis, Loss of Heterozygosity, Lung Neoplasms/genetics, Middle Aged, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Von Hippel-Lindau Tumor Suppressor Protein, von Hippel-Lindau Disease",

author = "S Miyakis and T Liloglou and S Kearney and G Xinarianos and Spandidos, {D A} and Field, {J K}",

year = "2003",

month = mar,

day = "1",

doi = "10.1016/s0169-5002(02)00506-8",

language = "English",

volume = "39",

pages = "273--7",

journal = "Lung Cancer",

issn = "0169-5002",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas

AU - Miyakis, S

AU - Liloglou, T

AU - Kearney, S

AU - Xinarianos, G

AU - Spandidos, D A

AU - Field, J K

PY - 2003/3/1

Y1 - 2003/3/1

N2 - In this study we have examined 79 primary non-small cell lung tumours for the presence of mutations of the VHL gene as well as for allelic imbalance at the gene surrounding loci. While allelic imbalance was found in 83% of specimens, frequently affecting the whole 3p25-p26 region, no mutations were detected in the VHL coding region. The fractional regional loss (FRL) was significantly higher in squamous cell carcinomas (0.746) than adenocarcinomas (0.493) (Wilcoxon P=0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC.

AB - In this study we have examined 79 primary non-small cell lung tumours for the presence of mutations of the VHL gene as well as for allelic imbalance at the gene surrounding loci. While allelic imbalance was found in 83% of specimens, frequently affecting the whole 3p25-p26 region, no mutations were detected in the VHL coding region. The fractional regional loss (FRL) was significantly higher in squamous cell carcinomas (0.746) than adenocarcinomas (0.493) (Wilcoxon P=0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC.

KW - Adenocarcinoma/genetics

KW - Aged

KW - Carcinoma, Non-Small-Cell Lung/genetics

KW - Carcinoma, Squamous Cell/genetics

KW - Chromosomes, Human, Pair 3

KW - DNA Mutational Analysis

KW - Genes, Tumor Suppressor

KW - Humans

KW - Ligases/analysis

KW - Loss of Heterozygosity

KW - Lung Neoplasms/genetics

KW - Middle Aged

KW - Tumor Suppressor Proteins

KW - Ubiquitin-Protein Ligases

KW - Von Hippel-Lindau Tumor Suppressor Protein

KW - von Hippel-Lindau Disease

U2 - 10.1016/s0169-5002(02)00506-8

DO - 10.1016/s0169-5002(02)00506-8

M3 - Article (journal)

C2 - 12609565

SN - 0169-5002

VL - 39

SP - 273

EP - 277

JO - Lung Cancer

JF - Lung Cancer

IS - 3

ER -

Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this