• Reader in Microbial Genetics, Biology

Accepting PhD Students

  • 360 Citations
  • 11 h-Index
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Personal profile


I have always been fascinated about Biology, since an early age when I learned that Biology means the study of life and I felt that life was definitely worth studying! Later on, I became interested in genetics as a way of understanding molecular mechanisms and as an undergraduate student in Swansea University I finally developed my interest for the wonderful Streptomyces bacterial genus, it’s complex biology and intricate regulatory pathways which lead to the production of many useful compounds such as antibiotics.

After being an undergraduate in Swansea University I decided to continue my research in Prof. Paul Dyson’s laboratory, working on the regulation of stress responses in the bacterial genus Streptomyces, and obtaining my PhD in 2008.

I then moved onto a post-doctoral position in INBIOTEC, a biotechnology institute in León, Spain, working on signal transduction, genome sequencing and proteome analysis in Actinobacteria.

In 2011 I joined Prof. Mervyn Bibb’s research group as a post-doctoral scientist at the John Innes Centre working on the regulation of several antibiotics including chloramphenicol, cinnamycin and the medically relevant gene cluster leading to the production of the novel lantibiotic microbisporicin. I also developed genetic tools to work with actinomycetes and worked with Prof. Barrie Wilkinson studying virulence factors in the opportunistic pathogen Pseudomonas aeruginosa in order to use these as potential drug targets.

In 2015 I joined the fantastic Biology Department at EHU as a Senior Lecturer in Microbial Genetics.  I am also final year tutor for all of the programmes in the Biology Department.

Research interests

My research interests are focused on understanding the complex regulatory pathways that lead to antibiotic production in Actinobacteria with a particular interest in lantibiotics as well as the study of the regulation of resistance mechanisms in antibiotic producing bacteria (the likely source of clinically relevant antibiotic resistance) and to characterise new gene clusters encoding novel compounds with antibiotic activity. To know more about my research group and current projects please visit the Actinomycetes Biology and Antibiotic discovery research page.


  • Programme Leader for BSc (Hons) Genetics
  • Final year tutor for all Biology Department Degrees
  • Modules taught include:
  •     Cellular Form and Function (Module Leader)
  •     Molecular Genetics (Module Leader)
  •     Laboratory Masterclass (Tutor)
  •     Research Methods in Biology (Tutor)
  •     Final Year Dissertation (Module Leader)
  •     Applications of Genetics (Tutor)
  •     Current Issues in Biology (Tutor)

Education/Academic qualification

PhD, Swansea University

… → 2008

Biological Sciences, BSc, University of Valencia

… → 2004

Genetics and Biochemistry, BSc, Swansea University

… → 2003

Teaching in Higher Education, PGCert, Edge Hill University

External positions

Post-doctoral Scientist, John Innes Centre


Post-doctoral, Inbiotec: Instituto de Biotecnologia de Leon


  • QH301 Biology
  • microbiology
  • actinomycetes
  • antibiotic discovery
  • QH426 Genetics
  • microbial genetics
  • gene regulation

Fingerprint Dive into the research topics where LORENA FERNANDEZ-MARTINEZ is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Streptomyces coelicolor Medicine & Life Sciences
Streptomyces Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Genes Medicine & Life Sciences
Genome Medicine & Life Sciences
Actinobacteria Medicine & Life Sciences
Phosphates Medicine & Life Sciences
Immunosuppressive Agents Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2009 2018

  • 360 Citations
  • 11 h-Index
  • 15 Article
5 Citations (Scopus)
1 Downloads (Pure)

Expanding Primary Metabolism Helps Generate the Metabolic Robustness To Facilitate Antibiotic Biosynthesis in Streptomyces

Schniete, J. K., Cruz-Morales, P., Selem-Mojica, N., Fernández-Martínez, L., Hunter, I. S., Barona-Gomez, F. & Hoskisson, P. A., 6 Feb 2018, In : mBio. 9, 1e, p. 1-13

Research output: Contribution to journalArticleResearch

Open Access
Pyruvate Kinase
Gene Duplication
Streptomyces coelicolor
5 Citations (Scopus)

Regulation of specialised metabolites in Actinobacteria – Expanding the paradigms

Hoskisson, P. A. & Ferandez-Martinez, L., 6 Apr 2018, In : Environmental Microbiology Reports. p. 1-8

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Antifungal Agents
Biosynthetic Pathways
Therapeutic Uses
Immunosuppressive Agents
38 Citations (Scopus)

Symbiont-mediated RNA interference in insects

Whitten, M. M. A., Facey, P. D., Del Sol, R., Fernández-Martínez, L. T., Evans, M. C., Mitchell, J. J., Bodger, O. G. & Dyson, P. J., 24 Feb 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1825, p. 20160042

Research output: Contribution to journalArticleResearchpeer-review

RNA Interference
RNA interference
14 Citations (Scopus)

ArelA-dependent regulatory cascade for auto-induction of microbisporicin production inMicrobispora corallina

Fernández-Martínez, L. T., Gomez-Escribano, J. P. & Bibb, M. J., 4 May 2015, In : Molecular Microbiology. 97, 3, p. 502-514

Research output: Contribution to journalArticleResearchpeer-review

Sigma Factor
Activator Appliances
Regulator Genes
30 Citations (Scopus)

New Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712

Fernandez-Martinez, L. T., Borsetto, C., Gomez-Escribano, J. P., Bibb, M. J., Al-Bassam, M. M., Chandra, G. & Bibb, M. J., 1 Dec 2014, In : Antimicrobial Agents and Chemotherapy. 58, 12, p. 7441-7450 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Multigene Family
Acyl Carrier Protein

Projects 2017 2019

Activities 2002 2018

  • 4 Membership of network
  • 1 Membership of committee

Royal Society of Biology (External organisation)


Activity: Membership typesMembership of network

Society for Applied Microbiology (External organisation)


Activity: Membership typesMembership of network

NPRONET (External organisation)


Activity: Membership typesMembership of network

Microbiology Society (External organisation)


Activity: Membership typesMembership of committee

Microbiology Society (External organisation)

Sep 2002 → …

Activity: Membership typesMembership of network