LORENA FERNANDEZ-MARTINEZ

Dr

  • Reader in Microbial Genetics, Biology

Accepting PhD Students

20092019
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Personal profile

Biography

I have always been fascinated about Biology, since an early age when I learned that Biology means the study of life and I felt that life was definitely worth studying! Later on, I became interested in genetics as a way of understanding molecular mechanisms and as an undergraduate student in Swansea University I finally developed my interest for the wonderful Streptomyces bacterial genus, it’s complex biology and intricate regulatory pathways which lead to the production of many useful compounds such as antibiotics.

After being an undergraduate in Swansea University I decided to continue my research in Prof. Paul Dyson’s laboratory, working on the regulation of stress responses in the bacterial genus Streptomyces, and obtaining my PhD in 2008.

I then moved onto a post-doctoral position in INBIOTEC, a biotechnology institute in León, Spain, working on signal transduction, genome sequencing and proteome analysis in Actinobacteria.

In 2011 I joined Prof. Mervyn Bibb’s research group as a post-doctoral scientist at the John Innes Centre working on the regulation of several antibiotics including chloramphenicol, cinnamycin and the medically relevant gene cluster leading to the production of the novel lantibiotic microbisporicin. I also developed genetic tools to work with actinomycetes and worked with Prof. Barrie Wilkinson studying virulence factors in the opportunistic pathogen Pseudomonas aeruginosa in order to use these as potential drug targets.

In 2015 I joined the fantastic Biology Department at EHU as a Senior Lecturer in Microbial Genetics.  I am also final year tutor for all of the programmes in the Biology Department.

Research interests

My research interests are focused on understanding the complex regulatory pathways that lead to antibiotic production in Actinobacteria with a particular interest in lantibiotics as well as the study of the regulation of resistance mechanisms in antibiotic producing bacteria (the likely source of clinically relevant antibiotic resistance) and to characterise new gene clusters encoding novel compounds with antibiotic activity. To know more about my research group and current projects please visit the Actinomycetes Biology and Antibiotic discovery research page.

Teaching

  • Programme Leader for BSc (Hons) Genetics
  • Final year tutor for all Biology Department Degrees
  • Modules taught include:
  •     Cellular Form and Function (Module Leader)
  •     Molecular Genetics (Module Leader)
  •     Laboratory Masterclass (Tutor)
  •     Research Methods in Biology (Tutor)
  •     Final Year Dissertation (Module Leader)
  •     Applications of Genetics (Tutor)
  •     Current Issues in Biology (Tutor)

Education/Academic qualification

PhD, Swansea University

… → 2008

Biological Sciences, BSc, University of Valencia

… → 2004

Genetics and Biochemistry, BSc, Swansea University

… → 2003

Teaching in Higher Education, PGCert, Edge Hill University

External positions

Post-doctoral Scientist, John Innes Centre

20112015

Post-doctoral, Inbiotec: Instituto de Biotecnologia de Leon

Keywords

  • QH301 Biology
  • microbiology
  • actinomycetes
  • antibiotic discovery
  • QH426 Genetics
  • microbial genetics
  • gene regulation

Fingerprint Dive into the research topics where LORENA FERNANDEZ-MARTINEZ is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Streptomyces coelicolor Medicine & Life Sciences
Streptomyces Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Genes Medicine & Life Sciences
Genome Medicine & Life Sciences
Actinobacteria Medicine & Life Sciences
Phosphates Medicine & Life Sciences
Immunosuppressive Agents Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2009 2018

Expanding Primary Metabolism Helps Generate the Metabolic Robustness To Facilitate Antibiotic Biosynthesis in Streptomyces

Schniete, J. K., Cruz-Morales, P., Selem-Mojica, N., Fernández-Martínez, L., Hunter, I. S., Barona-Gomez, F. & Hoskisson, P. A., 6 Feb 2018, In : mBio. 9, 1e, p. 1-13

Research output: Contribution to journalArticleResearch

Open Access
File
Pyruvate Kinase
Gene Duplication
Streptomyces
Genome
Streptomyces coelicolor

Regulation of specialised metabolites in Actinobacteria – Expanding the paradigms

Hoskisson, P. A. & Ferandez-Martinez, L., 6 Apr 2018, In : Environmental Microbiology Reports. p. 1-8

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Actinobacteria
Antifungal Agents
Biosynthetic Pathways
Therapeutic Uses
Immunosuppressive Agents

Symbiont-mediated RNA interference in insects

Whitten, M. M. A., Facey, P. D., Del Sol, R., Fernández-Martínez, L. T., Evans, M. C., Mitchell, J. J., Bodger, O. G. & Dyson, P. J., 24 Feb 2016, In : Proceedings of the Royal Society B: Biological Sciences. 283, 1825, p. 20160042

Research output: Contribution to journalArticleResearchpeer-review

File
RNA Interference
symbiont
RNA interference
symbionts
Insects

ArelA-dependent regulatory cascade for auto-induction of microbisporicin production inMicrobispora corallina

Fernández-Martínez, L. T., Gomez-Escribano, J. P. & Bibb, M. J., 4 May 2015, In : Molecular Microbiology. 97, 3, p. 502-514

Research output: Contribution to journalArticleResearchpeer-review

File
Sigma Factor
Activator Appliances
Bacteriocins
Actinobacteria
Regulator Genes

New Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712

Fernandez-Martinez, L. T., Borsetto, C., Gomez-Escribano, J. P., Bibb, M. J., Al-Bassam, M. M., Chandra, G. & Bibb, M. J., 29 Sep 2014, In : Antimicrobial Agents and Chemotherapy. 58, 12, p. 7441-7450

Research output: Contribution to journalArticleResearchpeer-review

File
Streptomyces
Chloramphenicol
Multigene Family
Genes
Acyl Carrier Protein

Projects 2017 2019

Activities 2002 2018

  • 4 Membership of network
  • 1 Membership of committee

Royal Society of Biology (External organisation)

LORENA FERNANDEZ-MARTINEZ (Member)
2018

Activity: Membership typesMembership of network

Society for Applied Microbiology (External organisation)

LORENA FERNANDEZ-MARTINEZ (Member)
2016

Activity: Membership typesMembership of network

NPRONET (External organisation)

LORENA FERNANDEZ-MARTINEZ (Member)
2015

Activity: Membership typesMembership of network

Microbiology Society (External organisation)

LORENA FERNANDEZ-MARTINEZ (Member)
20132019

Activity: Membership typesMembership of committee

Microbiology Society (External organisation)

LORENA FERNANDEZ-MARTINEZ (Member)
Sep 2002 → …

Activity: Membership typesMembership of network