Personal profile
Biography
Dr Craig Keenan is a Senior Lecturer in Biomedical Science within the Medical School at Edge Hill University. Craig graduated from the University of Liverpool (UoL) with an MChem in Medicinal Chemistry w/Pharmacology before going on to complete an MRes in Biomedical Science and then gaining his PhD in Musculoskeletal Biology from UoL, focussing on the rare disease Alkaptonuria, its identification and inhibition in pre-clinical models, and the development of severe osteoarthritis associated with the disease.
Craig has presented at National/International conferences including Bone Research Society; British Society for Matrix Biology; Rheumatology; International Workshop on Alkaptonuria; International Workshop on the CCN Family of Genes; Osteoarthritis Research Society International (OARSI) and the International Medical Postgraduate Conference. He has published his work in Annals of Rheumatic Diseases; Journal of Inherited Metabolic Disease Reports; Osteoarthritis & Cartilage; Disease Models & Mechanisms and European Cells and Materials.
Research interests
Research interests include: pathogenesis of osteoarthritis; the identification of novel targets to help prevent and progression of osteoarthritis; the role of microRNAs in osteoarthritis and Alkaptonuria (rare metabolic degenerative joint disease); the role of nutrients in osteoarthritis; widening participation/access in medicine (developing resources/programmes to support underrepresented students from diverse backgrounds to successfully apply for a place in medical school)
Education/Academic qualification
Musculoskeletal Biology, PhD, University of Liverpool
2010 → 2014
Biomedical Science, MRes, University of Liverpool
2009 → 2010
MChem - Medicinal Chemistry with Pharmacology, Other, University of Liverpool
2004 → 2008
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Collaborations and top research areas from the last five years
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Loss of the RNA Binding Protein HuR in Early Murine Limb Mesenchyme Does Not Affect Development but Leads to Impaired Bone Homeostasis in Adulthood
Fu, S., Johnson, K. A., Winstanley-Zarach, P., Ersoy, U., Adlmanninger, E., McDermott, B. T., KEENAN, C., Vasilaki, A., Kanakis, I., Milner, P. I., Van't Hof, R. J., Kontoyiannis, D., Bou-Gharios, G., Turner, D. A. & Tew, S. R., 20 Nov 2025, In: FASEB Journal. 39, 22, p. 1-14 e71222.Research output: Contribution to journal › Article (journal) › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)1 Downloads (Pure) -
Sex specific knee joint soft tissue mineralization with Fibrillin-1 mutation in male Tight Skin mice.
Keenan, C., Wang, X., Dikmen, T., Wen, Y., Ramos-Mucci, L., Shorter, E., Abraham, D., Bou-Gharios, G. & Poulet, B., 23 Jul 2025, In: European Cells and Materials. 52, p. 34-43 10 p.Research output: Contribution to journal › Article (journal) › peer-review
Open AccessFile9 Downloads (Pure) -
The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics
Ramos-Mucci, L., Elsheikh, A., Keenan, C., Eliasy, A., D’Aout, K., Bou-Gharios, G., Comerford, E. & Poulet, B., 30 May 2022, In: Arthritis Research and Therapy. 24, 1, p. 128 128.Research output: Contribution to journal › Article (journal) › peer-review
Open AccessFile9 Link opens in a new tab Citations (Scopus)89 Downloads (Pure) -
Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Wilson, P. J. M., Ranganath, L. R., Jarvis, J. C., Bou-Gharios, G. & Gallagher, J. A., 1 Feb 2021, In: Calcified Tissue International. 108, 2, p. 207-218 12 p.Research output: Contribution to journal › Article (journal) › peer-review
Open AccessFile12 Link opens in a new tab Citations (Scopus)71 Downloads (Pure) -
Cartilage-Specific Cre Recombinase Transgenes/Alleles in the Mouse
Kanakis, I., Alhashmi, M., Liu, K., Keenan, C., Ramos, M. L., Poulet, B. & Bou-Gharios, G., 15 Dec 2020, Chondrocytes: Methods and Protocols. Haqqi, T. & Lefebvre, V. (eds.). Springer, Vol. 2245. p. 23-38 16 p. (Methods in Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Link opens in a new tab Citation (Scopus)
Projects
- 3 Finished
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Medical Schools Council Careers Advisors & Teachers Conference
LEADBETTER, P. (PI) & KEENAN, C. (CoI)
28/06/23 → 28/06/23
Project: Other
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Medical Schools Council Pathways Programme
LEADBETTER, P. (PI) & KEENAN, C. (CoI)
3/04/23 → 10/07/24
Project: Other
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Medical Schools Council Careers Advisors & Careers Advisor Conference
LEADBETTER, P. (PI) & KEENAN, C. (PI)
16/06/22 → 16/06/22
Project: Other