CLAIRE HARPER

2025

Trophoblast-derived factors drive human mesenchymal stem cell differentiation along an endothelial lineage: A model of early placental vasculogenesis

Harper, C. V., Eccles, L., Henstock, J. & Charnock, J. C., 31 Mar 2025, In: Reproductive Biology. 25, 1, p. 1-8 8 p., 100994.

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2024

Face-to-face vs. blended learning in higher education: a quantitative analysis of biological science student outcomes

HARPER, C., McCormick, L. & MARRON, L., 10 Jan 2024, In: International Journal of Educational Technology in Higher Education. 21, 1, p. 1-16 16 p., 2.

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Open Access

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2 Citations (Scopus)

33 Downloads (Pure)

2023

SKF96365 modulates activity of CatSper channels in human sperm

Torrezan-Nitao, E., Brown, S., Lefievre, L., Morris, J., Correia, J., Harper, C. & Publicover, S., 27 Apr 2023, (E-pub ahead of print) In: Molecular Human Reproduction. 29, 6

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3 Citations (Scopus)

25 Downloads (Pure)

2021

Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene

McNamara, A. V., Awais, R., Momiji, H., Dunham, L., Featherstone, K., Harper, C. V., Adamson, A. A., Semprini, S., Jones, N. A., Spiller, D. G., Mullins, J. J., Finkenstädt, B. F., Rand, D., White, M. R. H. & Davis, J. R. E., 1 Apr 2021, In: Endocrinology. 162, 4, bqaa249.

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Open Access

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4 Citations (Scopus)

58 Downloads (Pure)

2020

Calcium dynamics and chromatin remodeling underlie heterogeneity in prolactin transcription

Harper, C. V., McNamara, A. V., Spiller, D. G., Charnock, J. C., White, M. R. & Davis, J. R., 20 Oct 2020, In: Journal of Molecular Endocrinology.

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Open Access

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4 Citations (Scopus)

64 Downloads (Pure)

Multiplexing information flow through dynamic signalling systems

Minas, G., Woodcock, D. J., Ashall, L., Harper, C. V., White, M. R. H. & Rand, D. A., 3 Aug 2020, In: PLoS Computational Biology. 16, 8, p. e1008076

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Open Access

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7 Citations (Scopus)

64 Downloads (Pure)

2019

Multiplexing information flow through dynamic signalling systems

Minas, G., Woodcock, D. J., Ashall, L., Harper, C., White, M. R. H. & Rand, D. A., 3 Dec 2019, (E-pub ahead of print) In: bioRxiv. p. 863159

Research output: Contribution to journal › Article (journal)

2018

Temperature regulates NF-κB dynamics and function through timing of A20 transcription

Harper, C. V., Woodcock, D. J., Lam, C., Garcia-Albornoz, M., Adamson, A., Ashall, L., Rowe, W., Downton, P., Schmidt, L., West, S., Spiller, D. G., Rand, D. A. & White, M. R. H., 29 May 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5243-E5249

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Open Access

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48 Citations (Scopus)

92 Downloads (Pure)

2017

Asymmetry between Activation and Deactivation during a Transcriptional Pulse

Dunham, L. S. S., Momiji, H., Harper, C. V., Downton, P. J., Hey, K., McNamara, A., Featherstone, K., Spiller, D. G., Rand, D. A., Finkenstädt, B., White, M. R. H. & Davis, J. R. E., 27 Dec 2017, In: Cell Systems. 5, 6, p. 646-653.e5

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11 Citations (Scopus)

78 Downloads (Pure)

2016

Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

Ankers, J. M., Awais, R., Jones, N. A., Boyd, J., Ryan, S., Adamson, A. D., Harper, C. V., Bridge, L., Spiller, D. G., Jackson, D. A., Paszek, P., Sée, V. & White, M. R., 17 May 2016, In: eLife. 5

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Open Access

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44 Citations (Scopus)

102 Downloads (Pure)

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

Adamson, A., Boddington, C., Downton, P., Rowe, W., Bagnall, J., Lam, C., Maya-Mendoza, A., Schmidt, L., Harper, C. V., Spiller, D. G., Rand, D. A., Jackson, D. A., White, M. R. H. & Paszek, P., 6 Jul 2016, In: Nature Communications. 7, p. 12057 12057.

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63 Citations (Scopus)

146 Downloads (Pure)

2013

Quantifying intrinsic and extrinsic noise in gene transcription using the linear noise approximation: An application to single cell data

Finkenstädt, B., Woodcock, D. J., Komorowski, M., Harper, C. V., Davis, J. R. E., White, M. R. H. & Rand, D. A., 1 Dec 2013, In: Annals of Applied Statistics. 7, 4, p. 1960-1982 23 p.

Research output: Contribution to journal › Article (journal) › peer-review

Open Access

26 Citations (Scopus)

2012

Peritonitis activates transcription of the human prolactin locus in myeloid cells in a humanized transgenic rat model

Semprini, S., McNamara, A. V., Awais, R., Featherstone, K., Harper, C. V., McNeilly, J. R., Patist, A., Rossi, A. G., Dransfield, I., McNeilly, A. S., Davis, J. R. E., White, M. R. H. & Mullins, J. J., Jun 2012, In: Endocrinology. 153, 6, p. 2724-34 11 p.

Research output: Contribution to journal › Article (journal) › peer-review

8 Citations (Scopus)

2011

Dynamic analysis of stochastic transcription cycles

Harper, C. V., Finkenstädt, B., Woodcock, D. J., Friedrichsen, S., Semprini, S., Ashall, L., Spiller, D. G., Mullins, J. J., Rand, D. A., Davis, J. R. E. & White, M. R. H., Apr 2011, In: PLoS Biology. 9, 4, p. e1000607

Research output: Contribution to journal › Article (journal) › peer-review

189 Citations (Scopus)

Pulsatile patterns of pituitary hormone gene expression change during development

Featherstone, K., Harper, C. V., McNamara, A., Semprini, S., Spiller, D. G., McNeilly, J., McNeilly, A. S., Mullins, J. J., White, M. R. H. & Davis, J. R. E., 15 Nov 2011, In: Development. 138, 22, p. e2208

Research output: Contribution to journal › Article (journal) › peer-review

Pulsatile patterns of pituitary hormone gene expression change during development

Featherstone, K., Harper, C. V., McNamara, A., Semprini, S., Spiller, D. G., McNeilly, J., McNeilly, A. S., Mullins, J. J., White, M. R. H. & Davis, J. R. E., 1 Oct 2011, In: Journal of Cell Science. 124, 20, p. 3484-3491 8 p.

Research output: Contribution to journal › Article (journal) › peer-review

Open Access

27 Citations (Scopus)

Wnt signaling in estrogen-induced lactotroph proliferation

Giles, A., Madec, F., Friedrichsen, S., Featherstone, K., Chambers, T., Harper, C. V., Resch, J., Brabant, G. & Davis, J. R. E., 15 Feb 2011, In: Journal of Cell Science. 124, Pt 4, p. 540-7 8 p.

Research output: Contribution to journal › Article (journal) › peer-review

20 Citations (Scopus)

2010

Dynamic organisation of prolactin gene expression in living pituitary tissue

Harper, C. V., Featherstone, K., Semprini, S., Friedrichsen, S., McNeilly, J., Paszek, P., Spiller, D. G., McNeilly, A. S., Mullins, J. J., Davis, J. R. E. & White, M. R. H., 1 Feb 2010, In: Journal of Cell Science. 123, Pt 3, p. 424-30 7 p.

Research output: Contribution to journal › Article (journal) › peer-review

43 Citations (Scopus)

Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells

Turner, D. A., Paszek, P., Woodcock, D. J., Nelson, D. E., Horton, C. A., Wang, Y., Spiller, D. G., Rand, D. A., White, M. R. H. & Harper, C. V., 15 Aug 2010, In: Journal of Cell Science. 123, Pt 16, p. 2834-43 10 p.

Research output: Contribution to journal › Article (journal) › peer-review

96 Citations (Scopus)

Population robustness arising from cellular heterogeneity

Paszek, P., Ryan, S., Ashall, L., Sillitoe, K., Harper, C. V., Spiller, D. G., Rand, D. A. & White, M. R. H., 22 Jun 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11644-9 6 p.

Research output: Contribution to journal › Article (journal) › peer-review

153 Citations (Scopus)

2009

Bayesian inference of biochemical kinetic parameters using the linear noise approximation

Komorowski, M., Finkenstädt, B., Harper, C. V. & Rand, D. A., 19 Oct 2009, In: BMC Bioinformatics. 10, p. 343

Research output: Contribution to journal › Article (journal) › peer-review

86 Citations (Scopus)

Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Harper, C. V., Sillitoe, K., Ryan, S., Spiller, D. G., Unitt, J. F., Broomhead, D. S., Kell, D. B., Rand, D. A., Sée, V. & White, M. R. H., 10 Apr 2009, In: Science. 324, 5924, p. 242-6 5 p.

Research output: Contribution to journal › Article (journal) › peer-review

471 Citations (Scopus)

Real-time visualization of human prolactin alternate promoter usage in vivo using a double-transgenic rat model

Semprini, S., Friedrichsen, S., Harper, C. V., McNeilly, J. R., Adamson, A. D., Spiller, D. G., Kotelevtseva, N., Brooker, G., Brownstein, D. G., McNeilly, A. S., White, M. R. H., Davis, J. R. E. & Mullins, J. J., 1 Apr 2009, In: Molecular Endocrinology. 23, 4, p. 529-38 10 p.

Research output: Contribution to journal › Article (journal) › peer-review

31 Citations (Scopus)

2008

Dynamic resolution of acrosomal exocytosis in human sperm

HARPER, C., Cummerson, J. A., White, M. R. H., Publicover, S. J. & Johnson, P. M., 1 Jul 2008, In: Journal of Cell Science. 121, Pt 13, p. 2130-5 6 p.

Research output: Contribution to journal › Article (journal) › peer-review

46 Citations (Scopus)

Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling

Adamson, A. D., Friedrichsen, S., Semprini, S., Harper, C. V., Mullins, J. J., White, M. R. H. & Davis, J. R. E., 28 Feb 2008, In: Endocrinology. 149, 2, p. 687-94 8 p.

Research output: Contribution to journal › Article (journal) › peer-review

46 Citations (Scopus)

Reconstruction of transcriptional dynamics from gene reporter data using differential equations

Finkenstädt, B., Heron, E. A., Komorowski, M., Edwards, K., Tang, S., Harper, C. V., Davis, J. R. E., White, M. R. H., Millar, A. J. & Rand, D. A., 15 Dec 2008, In: Bioinformatics. 24, 24, p. 2901-7 7 p.

Research output: Contribution to journal › Article (journal) › peer-review

56 Citations (Scopus)

2006

Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa

Billington, R. A., Harper, C., Bellomo, E. A., Publicover, S., Barratt, C. L. R. & Genazzani, A. A., 30 Oct 2006, In: Fertility and Sterility. 86, 4, p. 891-8 8 p.

Research output: Contribution to journal › Article (journal) › peer-review

6 Citations (Scopus)

Kinetics of the progesterone-induced acrosome reaction and its relation to intracellular calcium responses in individual human spermatozoa

HARPER, C., Barratt, C. L. R., Publicover, S. J. & Kirkman-Brown, J. C., 31 Dec 2006, In: Biology of Reproduction. 75, 6, p. 933-9 7 p.

Research output: Contribution to journal › Article (journal) › peer-review

36 Citations (Scopus)

Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappaB signaling

Friedrichsen, S., Harper, C. V., Semprini, S., Wilding, M., Adamson, A. D., Spiller, D. G., Nelson, G., Mullins, J. J., White, M. R. H. & Davis, J. R. E., 1 Feb 2006, In: Endocrinology. 147, 2, p. 773-81 9 p.

Research output: Contribution to journal › Article (journal) › peer-review

45 Citations (Scopus)

2005

Reassessing the role of progesterone in fertilization--compartmentalized calcium signalling in human spermatozoa?

Harper, C. V. & Publicover, S. J., Oct 2005, In: Human Reproduction. 20, 10, p. 2675-80 6 p.

Research output: Contribution to journal › Article (journal) › peer-review

41 Citations (Scopus)

Secretory pathway Ca(2+)-ATPase (SPCA1) Ca(2)+ pumps, not SERCAs, regulate complex [Ca(2+)](i) signals in human spermatozoa

Harper, C., Wootton, L., Michelangeli, F., Lefièvre, L., Barratt, C. & Publicover, S., 15 Apr 2005, In: Journal of Cell Science. 118, Pt 8, p. 1673-85 13 p.

Research output: Contribution to journal › Article (journal) › peer-review

67 Citations (Scopus)

2004

Stimulation of human spermatozoa with progesterone gradients to simulate approach to the oocyte. Induction of [Ca(2+)](i) oscillations and cyclical transitions in flagellar beating

Harper, C. V., Barratt, C. L. R. & Publicover, S. J., 29 Oct 2004, In: Journal of Biological Chemistry. 279, 44, p. 46315-25 11 p.

Research output: Contribution to journal › Article (journal) › peer-review

159 Citations (Scopus)

2003

Encoding of progesterone stimulus intensity by intracellular [Ca2+] ([Ca2+]i) in human spermatozoa

Harper, C. V., Kirkman-Brown, J. C., Barratt, C. L. R. & Publicover, S. J., 1 Jun 2003, In: Biochemical Journal. 372, Pt 2, p. 407-17 11 p.

Research output: Contribution to journal › Article (journal) › peer-review

52 Citations (Scopus)

Dr CLAIRE HARPER

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